Desparkremoval$1.33Efficient Orzhov removal that answers most high-impact permanents at instant speed. It fills the same broad role of removing a problematic nonland threat, though it is narrower than destroying any permanent.
Vindicateremoval$0.95Classic sorcery-speed answer to any permanent, matching Angel of Despair's flexibility on a cheaper spell. It trades the body and flying for much lower mana cost.
Utter EndremovalBudget$0.28Exiles any nonland permanent at instant speed, giving clean broad removal in the same colors. It is slightly more expensive but often stronger because it exiles instead of destroys.
MortifyremovalBudget$0.27Versatile Orzhov removal that can hit either a creature or enchantment. It is not as broad as Angel of Despair, but it fills a similar flexible interaction slot at a much lower cost.
Anguished Unmakingremoval$12.94Premium Orzhov instant-speed removal for any nonland permanent. It is one of the closest functional upgrades, with exile and instant speed at a much lower mana cost.
Cleansing Novaremoval$0.37Broad removal spell that can clear creatures or artifacts/enchantments depending on the mode. While it is mass removal rather than single-target, it serves a similar board-control role in white-black decks.
Ashen RiderremovalBudget$0.33Large flying reanimation target with an enters-the-battlefield trigger that exiles a permanent, closely mirroring Angel of Despair's big body plus removal effect. It is often considered a stronger version because exile is more permanent.
Rite of Oblivionremoval$0.37Repeatable Orzhov removal that can destroy any nonland permanent with casualty support. It is cheaper and more flexible over time, though it requires setup and is sorcery speed.